Within drug discovery, R&D projects using synchrotron X-rays focus on challenges such as optimising and improving drugs and their effects, studying proteins and their active sites, and investigating modes of binding drug candidates to target proteins. Using the beamlines and tools at MAX IV, researchers from drug discovery companies find brand new starting points for developing novel pharmaceutical substances.
Easy and rapid access to brilliant synchrotron X-rays is a vital ingredient for three-dimensional structure determination of drug targets through crystallography, and for studying proteins and their active sites at atomic resolution. Scattering techniques can provide information on atomic or molecular scale structure and dynamics in solution upon external stimuli. Small-angle X-ray scattering, electron microscopy, ant other complementary techniques can give a broad understanding of different processes.
MAX IV offers state-of-the-art instruments and world-class tools for crystallography as well as high-throughput screening techniques.
Examples of research topics at MAX IV:
- Protein structure determination
- Small-molecular drugs, nanomaterials for medical application, and drug-delivery vehicles
- Rapid examination of microcrystals
- Protein dynamics in solution
- How reactions take place in proteins
- Characterisation of pharmaceutical active ingredients and formulas in situ
Popular techniques and beamlines:
- Macromolecular X-ray crystallography at BioMAX
- Small-angle X-ray scattering and X-ray Photon Correlation Spectroscopy at CoSAXS
- Coming soon: Serial crystallography at MicroMAX
- Fragment screening at the FragMAX platform
Discuss your research and innovation needs with us! Contact us at the MAX IV Industrial Relations Office and we will help you turn your research idea into an experiment and match it with the suitable methods and techniques for you.